GLP-1 Medication Chart: Complete Comparison of All GLP-1 Drugs in 2026
Complete GLP-1 medication chart comparing Wegovy, Ozempic, Zepbound, Mounjaro, Rybelsus, Saxenda, Trulicity, and Foundayo.
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Quick answer: GLP-1 medication chart
There are 8 major GLP-1 medications available in the US in 2026. Tirzepatide (Zepbound, Mounjaro) produces the most weight loss at up to 22.5%. Semaglutide (Wegovy, Ozempic) produces approximately 15%. The cheapest option is compounded semaglutide at $149/month. Foundayo (orforglipron) is the newest oral GLP-1, approved in April 2026. Use the chart below to compare all medications side by side.
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Complete GLP-1 medication comparison chart
| Medication | Active Ingredient | FDA Approval | Route | Dosing | Avg Weight Loss | Cost/Month (No Insurance) |
|---|---|---|---|---|---|---|
| Wegovy | Semaglutide | Weight management | Weekly injection | Up to 2.4 mg/week | ~15% | $199–$1,349 |
| Ozempic | Semaglutide | Type 2 diabetes | Weekly injection | Up to 2 mg/week | ~14% (off-label) | $892–$1,400 |
| Zepbound | Tirzepatide | Weight management, OSA | Weekly injection | Up to 15 mg/week | Up to 22.5% | $299–$1,059 |
| Mounjaro | Tirzepatide | Type 2 diabetes | Weekly injection | Up to 15 mg/week | ~20% (off-label) | $1,023–$1,029 |
| Rybelsus | Semaglutide | Type 2 diabetes | Daily oral tablet | Up to 14 mg/day | ~4–6% (T2D dose) | $800–$950 |
| Saxenda | Liraglutide | Weight management | Daily injection | Up to 3 mg/day | ~8% | $1,300+ |
| Trulicity | Dulaglutide | Type 2 diabetes | Weekly injection | Up to 4.5 mg/week | ~5% (T2D dose) | $800–$970 |
| Foundayo | Orforglipron | Weight management (2026) | Daily oral tablet | Up to 36 mg/day | ~12–13% | ~$149 |
| Compounded semaglutide | Semaglutide | Not FDA-approved | Weekly injection | Up to 2.4 mg/week | ~15% (expected) | $149–$299 |
Weight loss percentages are from pivotal clinical trials. Individual results vary. See our GLP-1 cost guide for detailed pricing.
Side effects comparison
| Medication | Nausea | Diarrhea | Constipation | Vomiting |
|---|---|---|---|---|
| Semaglutide (Wegovy) | 44% | 31% | 24% | 24% |
| Tirzepatide (Zepbound) | 25–31% | 18–23% | 11–17% | 6–12% |
| Liraglutide (Saxenda) | 35% | 21% | 19% | 12% |
| Orforglipron (Foundayo) | 25–30% | 15–20% | 10–15% | 8–12% |
How to choose the right GLP-1 medication
- Maximum weight loss: Choose tirzepatide (Zepbound) — up to 22.5% weight loss
- Lowest cost: Choose compounded semaglutide ($149–$299/month) or Foundayo (~$149/month)
- Oral preference: Choose Wegovy oral tablet, Rybelsus, or Foundayo
- Fewest side effects: Tirzepatide may have slightly fewer GI side effects than semaglutide
- Cardiovascular benefit: Semaglutide has the strongest cardiovascular evidence (SELECT trial)
- Sleep apnea: Zepbound is FDA-approved for obstructive sleep apnea in adults with obesity
- Insurance coverage: Check which medications your plan covers — Wegovy and Zepbound are most commonly covered
For a full comparison, see our GLP-1 comparison guide 2026 and best GLP-1 for weight loss guide.
FAQ
Which GLP-1 has the most weight loss?
Tirzepatide (Zepbound, Mounjaro) at up to 22.5%, followed by semaglutide (Wegovy) at ~15%.
Which GLP-1 is cheapest?
Compounded semaglutide ($149–$299/month) and Foundayo (~$149/month through LillyDirect).
Which are FDA-approved for weight loss?
Wegovy, Zepbound, Saxenda, and Foundayo. Ozempic and Mounjaro are approved for T2D but often used off-label.
What is the difference between Wegovy and Ozempic?
Both contain semaglutide. Wegovy is approved for weight management (2.4 mg), Ozempic for T2D (2 mg).
Is there an oral GLP-1?
Yes: Rybelsus (T2D), Wegovy oral tablets (weight management), and Foundayo (weight management, 2026).
Which has the fewest side effects?
Real-world data suggests tirzepatide may cause fewer GI side effects than semaglutide (28.5% vs 50.7%).
Can I switch between GLP-1 medications?
Yes. Your provider will guide the transition, which may involve starting at a lower dose of the new medication.
What is Foundayo?
Foundayo (orforglipron) is the first oral small-molecule GLP-1, approved April 2026 for weight management. ~12–13% weight loss, ~$149/month.
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Jessica M., 38
Texas
-47 lbs
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Compounded semaglutide
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David R., 52
Florida
-62 lbs
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Tirzepatide (Zepbound)
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Aisha K., 34
California
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Compounded semaglutide
Results vary. These testimonials reflect individual experiences and are not typical. Weight loss depends on diet, activity, and adherence to medication.
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